Nature Communications (May 2017)

The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion

  • Runqiu Jiang,
  • Junwei Tang,
  • Yun Chen,
  • Lei Deng,
  • Jie Ji,
  • Yu Xie,
  • Ke Wang,
  • Wei Jia,
  • Wen-Ming Chu,
  • Beicheng Sun

DOI
https://doi.org/10.1038/ncomms15129
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 15

Abstract

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The role of long noncoding RNAs in regulating T-cell differentiation within the tumour microenvironment is unclear. Here the authors identify a lncRNA that, through direct interactions with EGFR, promotes T-regulatory cell differentiation within the microenvironment of hepatocellular carcinoma, thus promoting tumour growth via immune suppression.