SARS-CoV-2 Neutralization Resistance Mutations in Patient with HIV/AIDS, California, USA

Abstract

We report persistent severe acute respiratory syndrome coronavirus 2 infection in a patient with HIV/AIDS; the virus developed spike N terminal domain and receptor binding domain neutralization resistance mutations. Our findings suggest that immunocompromised patients can harbor emerging variants of severe acute respiratory syndrome coronavirus 2.

Keywords

• SARS-CoV-2
• HIV/AIDS
• viral evolution
• immunocompromised
• COVID-19
• respiratory infections