Structural basis of resistance to herbicides that target acetohydroxyacid synthase

Thierry Lonhienne; Yan Cheng; Mario D. Garcia; Shu Hong Hu; Yu Shang Low; Gerhard Schenk; Craig M. Williams; Luke W. Guddat

doi:10.1038/s41467-022-31023-x

Nature Communications (Jun 2022)

Structural basis of resistance to herbicides that target acetohydroxyacid synthase

Thierry Lonhienne,
Yan Cheng,
Mario D. Garcia,
Shu Hong Hu,
Yu Shang Low,
Gerhard Schenk,
Craig M. Williams,
Luke W. Guddat

Affiliations

Thierry Lonhienne: School of Chemistry and Molecular Biosciences, The University of Queensland
Yan Cheng: School of Chemistry and Molecular Biosciences, The University of Queensland
Mario D. Garcia: School of Chemistry and Molecular Biosciences, The University of Queensland
Shu Hong Hu: School of Chemistry and Molecular Biosciences, The University of Queensland
Yu Shang Low: School of Chemistry and Molecular Biosciences, The University of Queensland
Gerhard Schenk: School of Chemistry and Molecular Biosciences, The University of Queensland
Craig M. Williams: School of Chemistry and Molecular Biosciences, The University of Queensland
Luke W. Guddat: School of Chemistry and Molecular Biosciences, The University of Queensland

DOI: https://doi.org/10.1038/s41467-022-31023-x
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

Read online

Acetohydroxyacid synthase (AHAS) is the target of more than 50 commercial herbicides, with many site-of-action resistance isolates identified in weeds. Here, the authors report the structural and kinetic characterizations to explain the effect AHAS mutations have on herbicide potency.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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