Indistinguishable gene expression between healthy eyes and eyes with unilateral exfoliative glaucoma

Abstract

Marcelo Ayala,1–3 Filip Cuklev41Eye Department, Skaraborg Hospital, Skövde, Sweden; 2Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden; 3Karolinska Institute, Solna, Sweden; 4TATAA Biocenter, Gothenburg, SwedenBackground: Glaucoma is an optic neuropathy associated with visual field loss. There are different types of glaucoma, among them exfoliative glaucoma. Glaucoma can present as unilateral or bilateral. The present study aimed to show the association between gene expression and exfoliation in unilateral glaucoma cases.Methods: Included patients were suffering from exfoliative glaucoma in one eye, meanwhile the other eye was healthy and used as a control. Lens capsule and conjunctival biopsies were taken from both eyes. Gene expression was analyzed.Results: Both groups were completely different at baseline regarding intraocular pressure, visual acuity before the operation, visual field damage, optic nerve damage, etc. As for gene expression, the only significant difference was found in CYP1B1 from lens capsules. None of the other genes studied showed differential expression in either lens capsules or conjunctival biopsies.Conclusion: No difference in gene expression was found between eyes with and without exfoliative glaucoma. Exfoliative glaucoma seems to be a bilateral disease, though the phenotype is not always clinically present.Keywords: exfoliation, glaucoma, gene expression, unilateral

Keywords

• exfoliation
• glaucoma
• gene expression
• unilateral.