Communications Biology (Jan 2021)

Mapping the immune environment in clear cell renal carcinoma by single-cell genomics

  • Nicholas Borcherding,
  • Ajaykumar Vishwakarma,
  • Andrew P. Voigt,
  • Andrew Bellizzi,
  • Jacob Kaplan,
  • Kenneth Nepple,
  • Aliasger K. Salem,
  • Russell W. Jenkins,
  • Yousef Zakharia,
  • Weizhou Zhang

DOI
https://doi.org/10.1038/s42003-020-01625-6
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 11

Abstract

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Borcherding and Vishwakarma et al. characterize the tumor immune microenvironment in treatment-naïve clear cell renal carcinoma patients using single-cell RNA- and T-cell receptor sequencing. They find CD8 + T cells and macrophages are enriched in tumor tissue, and identify a proliferative CD8 + T-cell population, which may be relevant for anti-cancer responses.