Nature Communications (Apr 2020)

Circadian regulation of mitochondrial uncoupling and lifespan

  • Matt Ulgherait,
  • Anna Chen,
  • Sophie F. McAllister,
  • Han X. Kim,
  • Rebecca Delventhal,
  • Charlotte R. Wayne,
  • Christian J. Garcia,
  • Yocelyn Recinos,
  • Miles Oliva,
  • Julie C. Canman,
  • Martin Picard,
  • Edward Owusu-Ansah,
  • Mimi Shirasu-Hiza

DOI
https://doi.org/10.1038/s41467-020-15617-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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Disruption of different components of molecular circadian clocks has varying effects on health and lifespan of model organisms. Here the authors show that loss of period extends life in drosophila melanogaster.