Radiation Oncology (Feb 2012)

Stereotactic body radiation therapy for liver tumours using flattening filter free beam: dosimetric and technical considerations

  • Mancosu Pietro,
  • Castiglioni Simona,
  • Reggiori Giacomo,
  • Catalano Maddalena,
  • Alongi Filippo,
  • Pellegrini Chiara,
  • Arcangeli Stefano,
  • Tozzi Angelo,
  • Lobefalo Francesca,
  • Fogliata Antonella,
  • Navarria Piera,
  • Cozzi Luca,
  • Scorsetti Marta

DOI
https://doi.org/10.1186/1748-717X-7-16
Journal volume & issue
Vol. 7, no. 1
p. 16

Abstract

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Abstract Purpose To report the initial institute experience in terms of dosimetric and technical aspects in stereotactic body radiation therapy (SBRT) delivered using flattening filter free (FFF) beam in patients with liver lesions. Methods and Materials From October 2010 to September 2011, 55 consecutive patients with 73 primary or metastatic hepatic lesions were treated with SBRT on TrueBeam using FFF beam and RapidArc technique. Clinical target volume (CTV) was defined on multi-phase CT scans, PET/CT, MRI, and 4D-CT. Dose prescription was 75 Gy in 3 fractions to planning target volume (PTV). Constraints for organs at risk were: 700 cc of liver free from the 15 Gy isodose, Dmax max 0.1 cc 15 Gy Results Forty-three patients with a single lesion, nine with two lesions and three with three lesions were treated with this protocol. Target and organs at risk objectives were met for all patients. Mean delivery time was 2.8 ± 1.0 min. Pre-treatment plan verification resulted in a Gamma Agreement Index of 98.6 ± 0.8%. Mean on-line co-registration shift of the daily CBCT to the simulation CT were: -0.08, 0.05 and -0.02 cm with standard deviations of 0.33, 0.39 and 0.55 cm in, vertical, longitudinal and lateral directions respectively. Conclusions SBRT for liver targets delivered by means of FFF resulted to be feasible with short beam on time.

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