The effect of temulawak extract (Curcuma xanthorrhiza) and gamma radiation exposure on the area of the free radical curve in the lungs of mice (Mus musculus)

Abstract

The interaction of radiation with cells will form free radicals. Free radicals can cause cell damage. The presence of free radicals contained in cells can be detected using Electron Spin Resonance. Antioxidant compounds can minimize free radicals. This study analyzed the effect of ginger extract and gamma radiation exposure on the area of free radical curves in the lungs of mice. 80 male mice were used in this study and were divisible into 3 groups, namely the negative control group, the non-extract radiation group, and the extract plus radiation group. Temulawak extract is given at a dose of 1,4 gr/kgBB; 2,0 gr/kgBB; 2,6 gr/kgBB; 3,2 gr/kgBB and 3,8 gr/kgBB. Gamma radiation exposure was given for 10, 20, 30, 40, and 50 minutes. The results showed that ginger extract, which was given as prevention from gamma radiation, reduced the area of the free radical curve from 0,630 cm2 to 0,004 cm2

Keywords

• the lungs, gamma radiation, ginger