Structural basis of lysophosphatidylserine receptor GPR174 ligand recognition and activation

Jiale Liang; Asuka Inoue; Tatsuya Ikuta; Ruixue Xia; Na Wang; Kouki Kawakami; Zhenmei Xu; Yu Qian; Xinyan Zhu; Anqi Zhang; Changyou Guo; Zhiwei Huang; Yuanzheng He

doi:10.1038/s41467-023-36575-0

Nature Communications (Feb 2023)

Structural basis of lysophosphatidylserine receptor GPR174 ligand recognition and activation

Jiale Liang,
Asuka Inoue,
Tatsuya Ikuta,
Ruixue Xia,
Na Wang,
Kouki Kawakami,
Zhenmei Xu,
Yu Qian,
Xinyan Zhu,
Anqi Zhang,
Changyou Guo,
Zhiwei Huang,
Yuanzheng He

Affiliations

Jiale Liang: Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology
Asuka Inoue: Graduate School of Pharmaceutical Sciences, Tohoku University
Tatsuya Ikuta: Graduate School of Pharmaceutical Sciences, Tohoku University
Ruixue Xia: Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology
Na Wang: Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology
Kouki Kawakami: Graduate School of Pharmaceutical Sciences, Tohoku University
Zhenmei Xu: Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology
Yu Qian: Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology
Xinyan Zhu: Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology
Anqi Zhang: HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology
Changyou Guo: HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology
Zhiwei Huang: HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology
Yuanzheng He: Laboratory of Receptor Structure and Signaling, HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology

DOI: https://doi.org/10.1038/s41467-023-36575-0
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 10

Abstract

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GPR174 is a lysophosphatidylserine (LysoPS) activated GPCR. Here, the authors report the cryo-EM structure of LysoPS-bound human GPR174 in complex with Gs protein. The study reveals how GPR174 recognizes the lipid ligand and engages Gs in a distinct binding mode.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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