Communications Biology (Sep 2022)
Spike-based adenovirus vectored COVID-19 vaccine does not aggravate heart damage after ischemic injury in mice
- Shanshan Gu,
- Zhongyan Chen,
- Xiangfu Meng,
- Ge Liu,
- He Xu,
- Liying Huang,
- Linwei Wu,
- Jixing Gong,
- Ding Chen,
- Bingqing Xue,
- Lihang Zhu,
- Zhongjun Wan,
- Jianqing Lin,
- Xiaolong Cai,
- Xiaoyan Zhang,
- Jia Wang,
- Donghui Zhang,
- Nan Cao
Affiliations
- Shanshan Gu
- Zhongshan School of Medicine and the Seventh Affiliated Hospital, Sun Yat-Sen University
- Zhongyan Chen
- Zhongshan School of Medicine and the Seventh Affiliated Hospital, Sun Yat-Sen University
- Xiangfu Meng
- State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine, National & Local Joint Engineering Research Center of High-throughput Drug Screening Technology, Hubei University
- Ge Liu
- Zhongshan School of Medicine and the Seventh Affiliated Hospital, Sun Yat-Sen University
- He Xu
- Zhongshan School of Medicine and the Seventh Affiliated Hospital, Sun Yat-Sen University
- Liying Huang
- Zhongshan School of Medicine and the Seventh Affiliated Hospital, Sun Yat-Sen University
- Linwei Wu
- Zhongshan School of Medicine and the Seventh Affiliated Hospital, Sun Yat-Sen University
- Jixing Gong
- State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine, National & Local Joint Engineering Research Center of High-throughput Drug Screening Technology, Hubei University
- Ding Chen
- Zhongshan School of Medicine and the Seventh Affiliated Hospital, Sun Yat-Sen University
- Bingqing Xue
- State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine, National & Local Joint Engineering Research Center of High-throughput Drug Screening Technology, Hubei University
- Lihang Zhu
- State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine, National & Local Joint Engineering Research Center of High-throughput Drug Screening Technology, Hubei University
- Zhongjun Wan
- State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine, National & Local Joint Engineering Research Center of High-throughput Drug Screening Technology, Hubei University
- Jianqing Lin
- Zhongshan School of Medicine and the Seventh Affiliated Hospital, Sun Yat-Sen University
- Xiaolong Cai
- GeneMedi Suzhou Biotechnology Co., Ltd
- Xiaoyan Zhang
- GeneMedi Suzhou Biotechnology Co., Ltd
- Jia Wang
- Zhongshan School of Medicine and the Seventh Affiliated Hospital, Sun Yat-Sen University
- Donghui Zhang
- State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine, National & Local Joint Engineering Research Center of High-throughput Drug Screening Technology, Hubei University
- Nan Cao
- Zhongshan School of Medicine and the Seventh Affiliated Hospital, Sun Yat-Sen University
- DOI
- https://doi.org/10.1038/s42003-022-03875-y
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 11
Abstract
The safety of spike-based adenovirus type-5 vectored COVID-19 vaccine is evaluated, showing it neither affects the survival and function of human cardiac cells and engineered heart tissues nor aggravates heart damage in mice after ischemic injury.
