Peptide Conjugates of a 2′‑O‑Methoxyethyl Phosphorothioate Splice-Switching Oligonucleotide Show Increased Entrapment in Endosomes

ACS Omega (Oct 2023)

Affiliations

Alyssa C. Hill: Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, Eidgenössische Technische Hochschule Zürich (ETH Zürich), Zürich, Switzerland
J. Philipp Becker: Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, Eidgenössische Technische Hochschule Zürich (ETH Zürich), Zürich, Switzerland
Daria Slominski: Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, Eidgenössische Technische Hochschule Zürich (ETH Zürich), Zürich, Switzerland
François Halloy: Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, Eidgenössische Technische Hochschule Zürich (ETH Zürich), Zürich, Switzerland
Christoffer Søndergaard: Roche Innovation Center Copenhagen (RICC), Hørsholm, Denmark
Jacob Ravn: Roche Innovation Center Copenhagen (RICC), Hørsholm, Denmark
Jonathan Hall: Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, Eidgenössische Technische Hochschule Zürich (ETH Zürich), Zürich, Switzerland

Abstract

No abstracts available.