Emerging Infectious Diseases (Nov 2011)

Close Similarity between Sequences of Hepatitis E Virus Recovered from Humans and Swine, France, 2008−2009

  • Jérôme Bouquet,
  • Sophie Tessé,
  • Aurélie Lunazzi,
  • Marc Eloit,
  • Nicolas Rose,
  • Elisabeth Nicand,
  • Nicole Pavio

DOI
https://doi.org/10.3201/eid1711.110616
Journal volume & issue
Vol. 17, no. 11
pp. 2018 – 2025

Abstract

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Frequent zoonotic transmission of hepatitis E virus (HEV) has been suspected, but data supporting the animal origin of autochthonous cases are still sparse. We assessed the genetic identity of HEV strains found in humans and swine during an 18-month period in France. HEV sequences identified in patients with autochthonous hepatitis E infection (n = 106) were compared with sequences amplified from swine livers collected in slaughterhouses (n = 43). Phylogenetic analysis showed the same proportions of subtypes 3f (73.8%), 3c (13.4%), and 3e (4.7%) in human and swine populations. Furthermore, similarity of >99% was found between HEV sequences of human and swine origins. These results indicate that consumption of some pork products, such as raw liver, is a major source of exposure for autochthonous HEV infection.

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