Marine Drugs (Feb 2006)

Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase

  • Jun'ichi Kobayashi,
  • Kunimi Kikuchi,
  • Naohito Aoki,
  • Shinya Mitsuhashi,
  • Tadashi Okada,
  • Hiroshi Shima,
  • Takaaki Kubota,
  • Yusuke Wakuda

DOI
https://doi.org/10.3390/md401009
Journal volume & issue
Vol. 4, no. 1
pp. 9 – 14

Abstract

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Abstract: Manzamenones A~C (1~3) and E~F (5~6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against TCPTP was 4 times more potent than that against protein tyrosine phosphatase-1B (PTP1B).

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