OncoTargets and Therapy (Dec 2019)
Low-Grade Chondrosarcoma In The Sellar Area: Case Report And Literature Review
Abstract
Zhen Zhang,* Li-Juan Pang,* Ning Wang, Zhong Li, Yu-Wen Cao, Wen-Hao Hu, Wei-Hua Liang, Jin-Fang Jiang, Hong Zou, Yan Qi Department of Pathology, Shihezi University School of Medicine & The First Affiliated Hospital to Shihezi University School of Medicine, Shihezi, Xinjiang 832002, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yan Qi; Hong ZouDepartment of Pathology, Shihezi University School of Medicine & The First Affiliated Hospital to Shihezi University School of Medicine, North 2 Road, Shihezi, Xinjiang 832002, People’s Republic of ChinaTel +86 15009932652; +86 18999737799Email [email protected]; [email protected]: Low-grade chondrosarcoma (LGC) is a very rare intracranial tumor, particularly in the sellar area. Herein, we describe an unusual case of LGC occurring in the sellar area. A 52-year-old man presented with diminution of vision for more than 3 months, but did not exhibit headaches reported in previous cases. MRI showed that the maximum size of the tumor was 7 cm on the left side of the saddle. We characterized the specific pathological characteristics. Histologically, the tumor had polypoid areas and a lobulated growth pattern under low-power examination. At high magnification, the tumor consisted of small cells with hyperchromatic nuclei in the cartilage matrix, with an alternating loose hypocellular zone and rich myxoid area. In our case, LGC needed to be distinguished from chordoma. Immunohistochemically, the tumor cells showed diffuse positivity for S-100 and vimentin, IDH1 was weakly cytoplasm positive. The Ki-67 labeling index was less than 5%. Additionally, AE1/3, EMA, and CK19 were negative, which could be used to exclude chordoma. This case report expands the literature on LGC and will help clinicians and pathologists better understand this entity.Keywords: low-grade chondrosarcoma, saddle area, differential diagnosis
