Manganese-functionalized MXene theranostic nanoplatform for MRI-guided synergetic photothermal/chemodynamic therapy of cancer
An Dong,
Wu Xin,
Gong Yaolin,
Li Wenlu,
Dai Guidong,
Lu Xiaofei,
Yu Liangmin,
Ren Wen Xiu,
Qiu Meng,
Shu Jian
Affiliations
An Dong
Frontiers Science Center for Deep Ocean Multispheres and Earth System, and Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, Ocean University of China, Qingdao266100, P. R. China
Wu Xin
Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, P. R. China
Gong Yaolin
Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, P. R. China
Li Wenlu
Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, P. R. China
Dai Guidong
Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, P. R. China
Lu Xiaofei
Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, P. R. China
Yu Liangmin
Frontiers Science Center for Deep Ocean Multispheres and Earth System, and Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, Ocean University of China, Qingdao266100, P. R. China
Ren Wen Xiu
Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, P. R. China
Qiu Meng
Frontiers Science Center for Deep Ocean Multispheres and Earth System, and Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, Ocean University of China, Qingdao266100, P. R. China
Shu Jian
Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, P. R. China
Two-dimensional transition metal carbides and nitrides (MXenes) nanosheets with high photothermal conversion efficiency as well as photothermal stability can efficiently generate remarkable hyperthermia for photothermal therapy (PTT) of cancer. However, mono-MXenes cannot exhibit precise diagnosis and treatment to complete ablation of cancer cells in the PTT process. To overcome this dilemma, an “all-in-one” nanoplatform of titanium carbide (Ti3C2) MXene-based composite nanosheets is developed for magnetic resonance imaging (MRI)-guided multi-modal hyperthermia and chemodynamic tumor ablation, which was achieved by bonding of manganese ion on the surface of Ti3C2, and then was the functionalized nanosheets was modified by biocompatible PEG (Mn-Ti3C2@PEG). Due to magnetic and Fenton-like catalytic properties of Mn components, Mn-Ti3C2@PEG not only acted as the contrast agents for T1-weighted MRI (relaxivity value of 1.05 mM−1 s−1), but also converted cellular H2O2 into highly toxic hydroxyl radicals (·OH) mediated chemodynamic therapy (CDT). Moreover, Furthermore, Mn-Ti3C2@PEG can efficiently suppressed tumor-growth by PTT, due to the high photothermal conversion capability and photothermal stability. As a proof-of-concept model, the as-designed Mn-Ti3C2@PEG nanoplatform shows simultaneous MRI and dual-modal treatment for effective suppression of tumor with minimized side effects both in vitro and in vivo, indicating the great potential for clinical cancer theranostics.
