Investigation of gadolinium doped manganese nano spinel ferrites via magnetic hypothermia therapy effect towards MCF-7 breast cancer
M. Tahir,
M. Fakhar-e-Alam,
Muhammad Asif,
M. Javaid Iqbal,
Aoun Abbas,
Mudassir Hassan,
Javed Rehman,
Qaisar Abbas Bhatti,
Ghulam Mustafa,
Asma A. Alothman,
Saikh Mohammad
Affiliations
M. Tahir
Department of Physics, Government College University, Faisalabad, 38000, Pakistan
M. Fakhar-e-Alam
Department of Physics, Government College University, Faisalabad, 38000, Pakistan; Corresponding author.
Muhammad Asif
Department of Physics, Government College University, Faisalabad, 38000, Pakistan; Corresponding author.
M. Javaid Iqbal
Department of Physics, Government College University, Faisalabad, 38000, Pakistan
Aoun Abbas
Department of Physics, Government College University, Faisalabad, 38000, Pakistan
Mudassir Hassan
Department of Zoology, Government College University, Faisalabad, 38000, Pakistan
Javed Rehman
State Key Laboratory of Metastable Materials Science and Technology, and School of Materials Science and Engineering, Yanshan University, Qinhuangdao, 066004, China; MEU Research Unit, Middle East University, Amman, 11831, Jordan
Qaisar Abbas Bhatti
Department of Chemistry, Faculty of Sciences, Mohi-Ud-Din Islamic University Nerian Sharif, Azad Jammu & Kashmir, 12010, Pakistan
Ghulam Mustafa
Department of Physics, BZU, Multan, Pakistan
Asma A. Alothman
Department of Chemistry, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia
Saikh Mohammad
Department of Chemistry, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia
Magnetic spinel ferrite nanoparticles (MSF-NPs) are potential candidates for biomedical applications, especially in cancer diagnosis and therapy due to their excellent physiochemical and magnetic properties. In the current study, MSF-NPs were fabricated by sol-gel auto combustion method. The crystal structure and surface morphology were confirmed by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The magnetic properties were studied by VSM (vibrating sample magnetometer). As increasing Gd3+ concentration, the saturation magnetization values decreased from (17.8-2.3) emu/g, while the coercivity decreased from (499-133) Oe at room temperature. Finally, the fabricated MSF-NPs were tested against anticancer activity by MTT assay. The IC50 = 21.27 μg/mL value was observed, showing the strong antiproliferative activity of these nanoparticles. These results suggested that the obtained MSF-NPs would be useful for remote-controlled hyperthermia therapy for cancer treatment and MRI application due to their excellent magnetic properties. These distinct properties make MSF-NPs most suitable for cancer treatment and bright Contrast Agents (T1-MRI).
