Sleep pattern and locomotor activity are impaired by doxorubicin in non-tumor-bearing rats
Fabio Santos Lira,
Andrea Maculano Esteves,
Gustavo Duarte Pimentel,
José Cesar Rosa,
Miriam Kannebley Frank,
Melise Oliveira Mariano,
Josiane Budni,
João Quevedo,
Ronaldo Vagner dos Santos,
Marco Túlio de Mello
Affiliations
Fabio Santos Lira
Exercise and Immunometabolism Research Group, Department of Physical Education, Universidade Estadual Paulista (UNESP), Presidente Prudente, SP, Brazil
Andrea Maculano Esteves
Faculdade de Ciências Aplicadas, Universidade Estadual de Campinas, Limeira, Brazil
Gustavo Duarte Pimentel
Laboratory of Research in Clinical Nutrition and Sports (Labince), Nutrition Faculty (FANUT), Federal University of Goias (UFG), Goiânia, GO, Brazil
José Cesar Rosa
Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brazil
Miriam Kannebley Frank
Faculdade de Ciências Aplicadas, Universidade Estadual de Campinas, Limeira, Brazil
Melise Oliveira Mariano
Departamento de Psicobiologia, Universidade Federal de São Paulo, Brazil
Josiane Budni
Laboratory of Neurosciences, National Institute for Translational Medicine, and Center of Excellence in Applied Neurosciences of Santa Catarina, Postgraduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, 88806-000 Criciúma, SC, Brazil
João Quevedo
Laboratory of Neurosciences, National Institute for Translational Medicine, and Center of Excellence in Applied Neurosciences of Santa Catarina, Postgraduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, 88806-000 Criciúma, SC, Brazil
Ronaldo Vagner dos Santos
Departamento de Biociências, Universidade Federal de São Paulo, Santos, Brazil
Marco Túlio de Mello
Departamento de Esportes, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Purpose: We sought explore the effects of doxorubicin on sleep patterns and locomotor activity. To investigate these effects, two groups were formed: a control group and a Doxorubicin (DOXO) group. Methods: Sixteen rats were randomly assigned to either the control or DOXO groups. The sleep patterns were examined by polysomnographic recording and locomotor activity was evaluated in an open-field test. Results: In the light period, the total sleep time and slow wave sleep were decreased, while the wake after sleep onset and arousal were increased in the DOXO group compared with the control group (p<0.05). In the dark period, the total sleep time, arousal, and slow wave sleep were increased, while the wake after sleep onset was decreased in the DOXO group compared with the control group (p<0.05). Moreover, DOXO induced a decrease of crossing and rearing numbers when compared control group (p<0.05). Conclusions: Therefore, our results suggest that doxorubicin induces sleep pattern impairments and reduction of locomotor activity.
