Mutual potentiation drives synergy between trimethoprim and sulfamethoxazole

Yusuke Minato; Surendra Dawadi; Shannon L. Kordus; Abiram Sivanandam; Courtney C. Aldrich; Anthony D. Baughn

doi:10.1038/s41467-018-03447-x

Nature Communications (Mar 2018)

Mutual potentiation drives synergy between trimethoprim and sulfamethoxazole

Yusuke Minato,
Surendra Dawadi,
Shannon L. Kordus,
Abiram Sivanandam,
Courtney C. Aldrich,
Anthony D. Baughn

Affiliations

Yusuke Minato: Department of Microbiology and Immunology, University of Minnesota Medical School
Surendra Dawadi: Department of Medicinal Chemistry, University of Minnesota
Shannon L. Kordus: Department of Microbiology and Immunology, University of Minnesota Medical School
Abiram Sivanandam: Department of Microbiology and Immunology, University of Minnesota Medical School
Courtney C. Aldrich: Department of Medicinal Chemistry, University of Minnesota
Anthony D. Baughn: Department of Microbiology and Immunology, University of Minnesota Medical School

DOI: https://doi.org/10.1038/s41467-018-03447-x
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 7

Abstract

Read online

The antibiotics trimethoprim (TMP) and sulfamethoxazole (SMX) synergistically inhibit bacterial tetrahydrofolate biosynthesis, apparently because SMX potentiates TMP activity. Here, Minato et al. identify a metabolic feedback loop in this pathway, revealing that TMP also potentiates SMX activity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal