Strength of immune selection in tumors varies with sex and age

Andrea Castro; Rachel Marty Pyke; Xinlian Zhang; Wesley Kurt Thompson; Chi-Ping Day; Ludmil B. Alexandrov; Maurizio Zanetti; Hannah Carter

doi:10.1038/s41467-020-17981-0

Nature Communications (Aug 2020)

Strength of immune selection in tumors varies with sex and age

Andrea Castro,
Rachel Marty Pyke,
Xinlian Zhang,
Wesley Kurt Thompson,
Chi-Ping Day,
Ludmil B. Alexandrov,
Maurizio Zanetti,
Hannah Carter

Affiliations

Andrea Castro: Department of Medicine, Division of Medical Genetics, University of California San Diego
Rachel Marty Pyke: Department of Medicine, Division of Medical Genetics, University of California San Diego
Xinlian Zhang: Department of Family Medicine and Public Health, Division of Biostatistics & Bioinformatics, University of California San Diego
Wesley Kurt Thompson: Department of Family Medicine and Public Health, Division of Biostatistics & Bioinformatics, University of California San Diego
Chi-Ping Day: Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health
Ludmil B. Alexandrov: Department of Cellular and Molecular Medicine, University of California San Diego
Maurizio Zanetti: Moores Cancer Center, University of California San Diego
Hannah Carter: Department of Medicine, Division of Medical Genetics, University of California San Diego

DOI: https://doi.org/10.1038/s41467-020-17981-0
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 9

Abstract

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Here the authors show that stronger immune selection and immune editing in females and younger patients lead to the accumulation of poorly presented driver mutations in tumors. These results may explain why young and female patients are characterized by lower response rates to immune checkpoint blockade therapies.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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