Crystal Structures of a Series of Hydroxamic Acids
Ibrahima Sory Sow,
Michel Gelbcke,
François Dufrasne,
Koen Robeyns
Affiliations
Ibrahima Sory Sow
Microbiology, Bioorganic and Macromolecular Chemistry Unit, Faculty of Pharmacy, Université Libre de Bruxelles (ULB), 1050 Brussels, Belgium
Michel Gelbcke
Microbiology, Bioorganic and Macromolecular Chemistry Unit, Faculty of Pharmacy, Université Libre de Bruxelles (ULB), 1050 Brussels, Belgium
François Dufrasne
Microbiology, Bioorganic and Macromolecular Chemistry Unit, Faculty of Pharmacy, Université Libre de Bruxelles (ULB), 1050 Brussels, Belgium
Koen Robeyns
Institute of Condensed Matter and Nanosciences (IMCN), Molecualr Chemistry, Materials and Catalysis (MOST), Université catholique de Louvain (UCLouvain), 1348 Louvain-la-Neuve, Belgium
The structure of four hydroxamic acids (HA) that show antifungal activities in complexes with several metals is revealed by single crystal diffraction. The structures of HA with C2, C6, C10, and C12 hydrocarbon chains are reported. The smallest member of the series, N-hydroxyacetamide (HA2), crystallizes in the centrosymmetric space group P21/c while those with longer chain lengths N-hydroxyhexanamide (HA6), N-hydroxydecanamide (HA10), and N-hydroxydodecanamide (HA12) crystallize in the space group P21, and display remarkable packing.
