Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots

Vuyelwa Ncapayi; Neethu Ninan; Thabang C. Lebepe; Sundararajan Parani; Aswathy Ravindran Girija; Richard Bright; Krasimir Vasilev; Rodney Maluleke; Ncediwe Tsolekile; Tetsuya Kodama; Oluwatobi S. Oluwafemi

doi:10.3390/ijms222212514

International Journal of Molecular Sciences (Nov 2021)

Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots

Vuyelwa Ncapayi,
Neethu Ninan,
Thabang C. Lebepe,
Sundararajan Parani,
Aswathy Ravindran Girija,
Richard Bright,
Krasimir Vasilev,
Rodney Maluleke,
Ncediwe Tsolekile,
Tetsuya Kodama,
Oluwatobi S. Oluwafemi

Affiliations

Vuyelwa Ncapayi: Department of Chemical Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, Johannesburg 2028, South Africa
Neethu Ninan: Academic Unit of STEM, University of South Australia, Mawson Lakes, SA 5095, Australia
Thabang C. Lebepe: Department of Chemical Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, Johannesburg 2028, South Africa
Sundararajan Parani: Department of Chemical Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, Johannesburg 2028, South Africa
Aswathy Ravindran Girija: Future Industries Institute, University of South Australia, Mawson Lakes, SA 5095, Australia
Richard Bright: Academic Unit of STEM, University of South Australia, Mawson Lakes, SA 5095, Australia
Krasimir Vasilev: Academic Unit of STEM, University of South Australia, Mawson Lakes, SA 5095, Australia
Rodney Maluleke: Department of Chemical Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, Johannesburg 2028, South Africa
Ncediwe Tsolekile: Department of Chemical Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, Johannesburg 2028, South Africa
Tetsuya Kodama: Department of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan
Oluwatobi S. Oluwafemi: Department of Chemical Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, Johannesburg 2028, South Africa

DOI: https://doi.org/10.3390/ijms222212514
Journal volume & issue: Vol. 22, no. 22
p. 12514

Abstract

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The link between the microbiome and cancer has led researchers to search for a potential probe for intracellular targeting of bacteria and cancer. Herein, we developed near infrared-emitting ternary AgInSe/ZnS quantum dots (QDs) for dual bacterial and cancer imaging. Briefly, water-soluble AgInSe/ZnS QDs were synthesized in a commercial kitchen pressure cooker. The as-synthesized QDs exhibited a spherical shape with a particle diameter of 4.5 ± 0.5 nm, and they were brightly fluorescent with a photoluminescence maximum at 705 nm. The QDs showed low toxicity against mouse mammary carcinoma (FM3A-Luc), mouse colon carcinoma (C26), malignant fibrous histiocytoma-like (KM-Luc/GFP) and prostate cancer cells, a greater number of accumulations in Staphylococcus aureus, and good cellular uptake in prostate cancer cells. This work is an excellent step towards using ternary QDs for diagnostic and guided therapy for prostate cancer.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

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