Revista Cubana de Investigaciones Biomédicas (Sep 2001)
Evaluación de un posible modelo experimental de aterosclerosis carotídea en conejos hipercolesterolémicos
Abstract
Se evaluó la utilidad de un procedimiento experimental para desarrollar aterosclerosis carotídea en conejos. Se estudiaron 18 animales divididos en 3 grupos, con 6 animales cada uno. Los animales fueron alimentados mediante pienso suplementado con 0,5 y 1 % de colesterol (grupos I y II, respectivamente), en tanto el III (control) solo con pienso. Se hicieron determinaciones bioquímicas antes de comenzar el experimento y en las semanas 4, 8 y 12, posteriores a la dieta. Se observó un aumento significativo en el peso de los animales de los grupos I y II en la semana 8 para p The advantages of an experimental procedure to develop carotid atherosclerosis in rabbits were evaluated. Eighteen animals distributed into 3 groups, 6 animals each, were examined. Animals were fed with fodder supplemented with 0.5 and 1% of cholesterol (group I and II respectively) whereas group 3 (control) was given only fodder. Biochemical determinations were performed before the experiments and at weeks 4, 8 and 12 after the dietary treatments. The animals´weight in groups I and II had significantly increased by the 8th week for a p< 0,05;hemoglobin and hematocrit values remained unchanged. Cholesterol substantially increased in groups I and II from the 4th week on. The morphometric study revealed that there were fatty streaks in both carotids of animals included in group 2, which proved the benefits of this experimental model of carotid atherosclerosis
