Colorectal cancer-derived extracellular vesicles induce liver premetastatic immunosuppressive niche formation to promote tumor early liver metastasis

• Xuyang Yang,
• Yaguang Zhang,
• Yang Zhang,
• Huifang Li,
• Li Li,
• Yangping Wu,
• Xiangzheng Chen,
• Lei Qiu,
• Junhong Han,
• Ziqiang Wang

Affiliations

Xuyang Yang

Colorectal Cancer Center, Department of General Surgery, State Key Laboratory of Biotherapy and Cancer Center, and Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University

Yaguang Zhang

State Key Laboratory of Biotherapy and Cancer Center, and Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University

Yang Zhang

Colorectal Cancer Center, Department of General Surgery, State Key Laboratory of Biotherapy and Cancer Center, and Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University

Huifang Li

Core Facility, Institute of Clinical Pathology, Department of Respiratory and Critical Care Medicine, and Department of Liver Surgery & Liver Transplantation, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy

Li Li

Core Facility, Institute of Clinical Pathology, Department of Respiratory and Critical Care Medicine, and Department of Liver Surgery & Liver Transplantation, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy

Yangping Wu

Core Facility, Institute of Clinical Pathology, Department of Respiratory and Critical Care Medicine, and Department of Liver Surgery & Liver Transplantation, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy

Xiangzheng Chen

Core Facility, Institute of Clinical Pathology, Department of Respiratory and Critical Care Medicine, and Department of Liver Surgery & Liver Transplantation, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy

Lei Qiu

State Key Laboratory of Biotherapy and Cancer Center, and Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University

Junhong Han

State Key Laboratory of Biotherapy and Cancer Center, and Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University

Ziqiang Wang

Colorectal Cancer Center, Department of General Surgery, State Key Laboratory of Biotherapy and Cancer Center, and Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University