CTLD1 on the prognosis of idiopathic membranous nephropathy: a single center study

Abstract

Objective To explore the clinical significance of serum C-type lectin domain 1（CTLD1） for prognosis of patients with idiopathic membranous nephropathy（IMN）. Methods A total of 116 patients with IMN diagnosed in Shengjing Hospital from September 2016 to December 2019 were selected as the case group, and healthy volunteers with age and gender matching in the physical examination center during the same period were selected as the health control group. Clinical data of patients in case group were collected and followed up for ≥ 2 years to record treatment and outcome. The expression level of PLAZR antigen and CTLD1 antigen epitope were detected by ELISA. The differences of clinical indexes between CTLD1 positive group and negative group were compared, and the prognostic influencing factors of IMN patients were analyzed. b>Results There was a statistical difference in CTLD1 expression level between health control group and case group（P<0.01）. The blood C3 level（Z=2.402, P=0.016） and anti-PLA2R antibody level（Z=2.266, P=0.023） in CTLD1 positive group were statistically higher than those in CTLD1 negative group. CTLD1 was positively correlated with blood C3（r=0.239, P=0.012） and anti-PLA2R antibody（r=0.233, P=0.016）, respectively. Cox regression analysis showed that high CTLD1 level was an unfavorable factor for disease remission （HR=0.734, P<0.05）, and positive CTLD1 predicted a poor prognosis for IMN patients（HR=0.628, P<0.05）. Conclusion CTLD1 epitope expression level is related to the prognosis of IMN patients, with a assessment and significance for outcome of IMN patients.

Keywords

• membranous nephropathy
• idiopathic
• phospholipase a2 receptor
• c-type lectin domain 1
• complement 3