Hemorrhagic Fever with Renal Syndrome Presenting with Hemophagocytic Lymphohistiocytosis

Abstract

Hemophagocytic lymphohistiocytosis--which is associated with a variety of infections, malignant neoplasms, autoimmune diseases, and immunodeficiencies--is an uncommon syndrome with a rapidly fatal outcome. We describe the first case of hemorrhagic fever with renal syndrome due to Hantaan virus presenting with reactive hemophagocytosis.

Keywords

• Hantaan virus
• Hemophagocytosis
• Hemorrhagic fever with renal syndrome
• South Korea