Macroamylasemia as the First Manifestation of Celiac Disease

Abstract

Macroamylasemia is a biochemical disorder characterized by an elevated serum amylase activity resulting from the circulation of a macromolecular complex of amylase with a serum component, often an immunoglobulin. The increased molecular weight of this complex prevents the normal renal excretion of the enzyme. A few cases of celiac patients with macroamylasemia have been published in whom the biochemical disorder disappeared after treatment with a gluten-free diet.

Keywords

• Gluten-free diet
• Maculopapular rash
• Anemia
• Celiac disease
• Macroamylasemia