Frontiers in Endocrinology (Aug 2022)
Role of microRNA alternation in the pathogenesis of gouty arthritis
- Zhipan Luo,
- Zhipan Luo,
- Zhipan Luo,
- Zhipan Luo,
- Fan Yang,
- Shaocheng Hong,
- Jianpeng Wang,
- Bangjie Chen,
- Liangyun Li,
- Liangyun Li,
- Liangyun Li,
- Junfa Yang,
- Yan Yao,
- Yan Yao,
- Yan Yao,
- Chenchen Yang,
- Chenchen Yang,
- Chenchen Yang,
- Ying Hu,
- Ying Hu,
- Ying Hu,
- Shuxian Wang,
- Shuxian Wang,
- Shuxian Wang,
- Tao Xu,
- Tao Xu,
- Tao Xu,
- Jun Wu
Affiliations
- Zhipan Luo
- The First Affifiliated Hospital, Anhui Medical University, Hefei, China
- Zhipan Luo
- Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China
- Zhipan Luo
- Anhui Institute of Innovative Drugs, Hefei, China
- Zhipan Luo
- School of Pharmacy, Anhui Medical University, Hefei, China
- Fan Yang
- The First Affifiliated Hospital, Anhui Medical University, Hefei, China
- Shaocheng Hong
- The First Affifiliated Hospital, Anhui Medical University, Hefei, China
- Jianpeng Wang
- The First Affifiliated Hospital, Anhui Medical University, Hefei, China
- Bangjie Chen
- The First Affifiliated Hospital, Anhui Medical University, Hefei, China
- Liangyun Li
- Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China
- Liangyun Li
- Anhui Institute of Innovative Drugs, Hefei, China
- Liangyun Li
- School of Pharmacy, Anhui Medical University, Hefei, China
- Junfa Yang
- Institute of clinical pharmacology, Anhui Medical University, Hefei, China
- Yan Yao
- Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China
- Yan Yao
- Anhui Institute of Innovative Drugs, Hefei, China
- Yan Yao
- School of Pharmacy, Anhui Medical University, Hefei, China
- Chenchen Yang
- Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China
- Chenchen Yang
- Anhui Institute of Innovative Drugs, Hefei, China
- Chenchen Yang
- School of Pharmacy, Anhui Medical University, Hefei, China
- Ying Hu
- Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China
- Ying Hu
- Anhui Institute of Innovative Drugs, Hefei, China
- Ying Hu
- School of Pharmacy, Anhui Medical University, Hefei, China
- Shuxian Wang
- Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China
- Shuxian Wang
- Anhui Institute of Innovative Drugs, Hefei, China
- Shuxian Wang
- School of Pharmacy, Anhui Medical University, Hefei, China
- Tao Xu
- Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China
- Tao Xu
- Anhui Institute of Innovative Drugs, Hefei, China
- Tao Xu
- School of Pharmacy, Anhui Medical University, Hefei, China
- Jun Wu
- Geriatric Department, The First Affifiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
- DOI
- https://doi.org/10.3389/fendo.2022.967769
- Journal volume & issue
-
Vol. 13
Abstract
Gouty arthritis is a common inflammatory disease. The condition is triggered by a disorder of uric acid metabolism, which causes urate deposition and gout flares. MicroRNAs are a class of conserved small non-coding RNAs that bind to the 3’ untranslated region (UTR) of mRNA and regulate the expression of a variety of proteins at the post-transcriptional level. In recent years, attention has been focused on the role of miRNAs in various inflammatory diseases, including gouty arthritis. It is thought that miRNAs may regulate immune function and inflammatory responses, thereby influencing the onset and progression of the disease. This article mainly reviewed the roles of miRNAs in the pathogenesis of gouty arthritis and prospected their potential as diagnostic and prognostic relevant biomarkers and as possible therapeutic targets.
Keywords
