British Columbia CARMA-CHIWOS Collaboration (BCC3): protocol for a community-collaborative cohort study examining healthy ageing with and for women living with HIV
Joel Singer,
Melanie Lee,
Angela Kaida,
Neora Pick,
Valerie Nicholson,
Rebecca Gormley,
Shayda A Swann,
Jason Brophy,
Amber R Campbell,
Allison Carter,
Chelsea Elwood,
Tsion Gebremedhen,
Elizabeth M King,
Vonnie Lee,
Evelyn J Maan,
Patience Magagula,
Sheila Nyman,
Davi Pang,
Tetiana Povshedna,
Jerilynn C Prior,
Shelly Tognazzini,
Melanie C M Murray,
Helene C F Cote
Affiliations
Joel Singer
15 School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada
Melanie Lee
3 Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada
Angela Kaida
2 British Columbia Women's Hospital and Health Centre Women’s Health Research Institute, Vancouver, British Columbia, Canada
Neora Pick
2 British Columbia Women's Hospital and Health Centre Women’s Health Research Institute, Vancouver, British Columbia, Canada
Valerie Nicholson
3 Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada
Rebecca Gormley
3 Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada
Shayda A Swann
1 Experimental Medicine, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada
Jason Brophy
5 Division of Infectious Diseases, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada
Amber R Campbell
2 British Columbia Women's Hospital and Health Centre Women’s Health Research Institute, Vancouver, British Columbia, Canada
Allison Carter
3 Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada
Chelsea Elwood
2 British Columbia Women's Hospital and Health Centre Women’s Health Research Institute, Vancouver, British Columbia, Canada
Tsion Gebremedhen
3 Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada
Elizabeth M King
2 British Columbia Women's Hospital and Health Centre Women’s Health Research Institute, Vancouver, British Columbia, Canada
Vonnie Lee
2 British Columbia Women's Hospital and Health Centre Women’s Health Research Institute, Vancouver, British Columbia, Canada
Evelyn J Maan
2 British Columbia Women's Hospital and Health Centre Women’s Health Research Institute, Vancouver, British Columbia, Canada
Patience Magagula
10 Afro-Caribbean Positive Network of BC, Vancouver, British Columbia, Canada
Sheila Nyman
11 Bear Rock Consulting, Lone Butte, British Columbia, Canada
Davi Pang
3 Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada
Tetiana Povshedna
13 Pathology and Laboratory Medicine, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada
Jerilynn C Prior
2 British Columbia Women's Hospital and Health Centre Women’s Health Research Institute, Vancouver, British Columbia, Canada
Shelly Tognazzini
3 Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada
Melanie C M Murray
2 British Columbia Women's Hospital and Health Centre Women’s Health Research Institute, Vancouver, British Columbia, Canada
Helene C F Cote
2 British Columbia Women's Hospital and Health Centre Women’s Health Research Institute, Vancouver, British Columbia, Canada
Introduction Women living with HIV (WLWH) experience accelerated ageing and an increased risk of age-associated diseases earlier in life, compared with women without HIV. This is likely due to a combination of viral factors, gender differences, hormonal imbalance and psychosocial and structural conditions. This interdisciplinary cohort study aims to understand how biological, clinical and sociostructural determinants of health interact to modulate healthy ageing in WLWH.Methods and analysis The British Columbia Children and Women: AntiRetroviral therapy and Markers of Aging-Canadian HIV Women’s Sexual and Reproductive Health Cohort Study (CARMA-CHIWOS) Collaboration (BCC3) study will enrol WLWH (n=350) and sociodemographically matched HIV-negative women (n=350) living in British Columbia. A subset of BCC3 participants will be past participants of CARMA, n≥1000 women and children living with and without HIV, 2008–2018 and/or CHIWOS, n=1422 WLWH, 2013–2018. Over two study visits, we will collect biological specimens for virus serologies, hormones and biological markers as well as administer a survey capturing demographic and sociostructural–behavioural factors. Sociodemographics, comorbidities, number and type of chronic/latent viral infections and hormonal irregularities will be compared between the two groups. Their association with biological markers and psychostructural and sociostructural factors will be investigated through multivariable regression and structural equation modelling. Retrospective longitudinal analyses will be conducted on data from past CARMA/CHIWOS participants. As BCC3 aims to follow participants as they age, this protocol will focus on the first study visits.Ethics and dissemination This study has been approved by the University of British Columbia Children’s and Women’s Research Ethics Board (H19-00896). Results will be shared in peer-reviewed journals, conferences and at community events as well as at www.hivhearme.ca and @HIV_HEAR_me. WLWH are involved in study design, survey creation, participant recruitment, data collection and knowledge translation. A Community Advisory Board will advise the research team throughout the study.
