Critical Care Explorations (Jun 2020)
Pediatric Sepsis Definition—A Systematic Review Protocol by the Pediatric Sepsis Definition Taskforce
- Kusum Menon, MD, MSc,
- Luregn J. Schlapbach, MD,
- Samuel Akech, MBChB, MMED,
- Andrew Argent, MBBCh, MD,
- Kathleen Chiotos, MD, MSCE,
- Mohammod Jobayer Chisti, MBBS, MMed, PhD,
- Jemila Hamid, PhD,
- Paul Ishimine, MD,
- Niranjan Kissoon, MD,
- Rakesh Lodha, MD,
- Cláudio Flauzino Oliveira, MD,
- Mark Peters, MBChB, PhD,
- Pierre Tissieres, MD, PhD,
- R. Scott Watson, MD, MPH,
- Matthew O. Wiens, PharmD, PhD,
- James L. Wynn, MD,
- Lauren R. Sorce, BSN, PhD,
- for the Pediatric Sepsis Definition Taskforce of the Society of Critical Care Medicine,
- Luregn J. Schlapbach,
- R. Scott Watson,
- Andrew Argent,
- Lauren R. Sorce,
- Elizabeth R. Alpern,
- Fran Balamuth,
- Tellen D. Bennett,
- Paolo Biban,
- Joe Carcillo,
- Enitan Carrol,
- Kathleen Chiotos,
- Mohammod Jobayer Chisti,
- Idris Evans,
- Lu Guoping,
- Mark W. Hall,
- David Inwald,
- Paul Ishimine,
- Michael Levin,
- Niranjan (Tex) Kissoon,
- Rakesh Lodha,
- Kathryn Maitland,
- Simon Nadel,
- Satoshi Nakagawa,
- Claudio Flauzino Oliveira,
- Mark Peters,
- Adrienne G. Randolph,
- Suchitra Ranjit,
- L. Nelson Sanchez-Pinto,
- Halden F. Scott,
- Daniela Carla Souza,
- Paul Tissieres,
- Juliane Bubeck Wardenburg,
- Scott L. Weiss,
- Wilson Milton Were,
- Matt Wiens,
- James L. Wynn,
- Jerry J. Zimmerman
Affiliations
- Kusum Menon, MD, MSc
- 1 Department of Pediatrics, Children’s Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON, Canada.
- Luregn J. Schlapbach, MD
- 2 Paediatric Critical Care Research Group, Child Health Research Centre, The University of Queensland, Brisbane, QLD, Australia.
- Samuel Akech, MBChB, MMED
- 4 KEMRI Wellcome Trust Research Program, Oxford, United Kingdom.
- Andrew Argent, MBBCh, MD
- 5 Department of Paediatrics and Child Health, Red Cross War Memorial Children’s Hospital and University of Cape Town, Cape Town, South Africa.
- Kathleen Chiotos, MD, MSCE
- 6 Department of Anesthesia and Critical Care Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA.
- Mohammod Jobayer Chisti, MBBS, MMed, PhD
- 7 International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
- Jemila Hamid, PhD
- 8 Children’s Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
- Paul Ishimine, MD
- 9 Department of Emergency Medicine, University of California San Diego, San Diego, CA.
- Niranjan Kissoon, MD
- 10 Department of Pediatrics, British Columbia Children’s Hospital, Vancouver, BC, Canada.
- Rakesh Lodha, MD
- 11 Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
- Cláudio Flauzino Oliveira, MD
- 12 Associação de Medicina Intensiva Brasileira, São Paulo, Brazil.
- Mark Peters, MBChB, PhD
- 13 University College London Great Ormond Street Institute of Child Health, London, United Kingdom.
- Pierre Tissieres, MD, PhD
- 14 Hospital de Bicetre, Paris, France.
- R. Scott Watson, MD, MPH
- 15 Center for Child Health, Behavior and Development, Seattle Children’s Research Institute, Seattle Children’s Hospital, Seattle, WA.
- Matthew O. Wiens, PharmD, PhD
- 16 University of British Columbia, Vancouver, BC, Canada.
- James L. Wynn, MD
- 18 Department of Pediatrics, University of Florida, Gainesville, FL.
- Lauren R. Sorce, BSN, PhD
- 19 Ann & Robert H. Lurie Children’s Hospital, Chicago, IL.
- for the Pediatric Sepsis Definition Taskforce of the Society of Critical Care Medicine
- Luregn J. Schlapbach
- R. Scott Watson
- Andrew Argent
- Lauren R. Sorce
- Elizabeth R. Alpern
- Fran Balamuth
- Tellen D. Bennett
- Paolo Biban
- Joe Carcillo
- Enitan Carrol
- Kathleen Chiotos
- Mohammod Jobayer Chisti
- Idris Evans
- Lu Guoping
- Mark W. Hall
- David Inwald
- Paul Ishimine
- Michael Levin
- Niranjan (Tex) Kissoon
- Rakesh Lodha
- Kathryn Maitland
- Simon Nadel
- Satoshi Nakagawa
- Claudio Flauzino Oliveira
- Mark Peters
- Adrienne G. Randolph
- Suchitra Ranjit
- L. Nelson Sanchez-Pinto
- Halden F. Scott
- Daniela Carla Souza
- Paul Tissieres
- Juliane Bubeck Wardenburg
- Scott L. Weiss
- Wilson Milton Were
- Matt Wiens
- James L. Wynn
- Jerry J. Zimmerman
- DOI
- https://doi.org/10.1097/CCE.0000000000000123
- Journal volume & issue
-
Vol. 2,
no. 6
p. e0123
Abstract
Objectives:. Sepsis is responsible for a substantial proportion of global childhood morbidity and mortality. However, evidence demonstrates major inaccuracies in the use of the term “sepsis” in clinical practice, coding, and research. Current and previous definitions of sepsis have been developed using expert consensus but the specific criteria used to identify children with sepsis have not been rigorously evaluated. Therefore, as part of the Society of Critical Care Medicine’s Pediatric Sepsis Definition Taskforce, we will conduct a systematic review to synthesize evidence on individual factors, clinical criteria, or illness severity scores that may be used to identify children with infection who have or are at high risk of developing sepsis-associated organ dysfunction and separately those factors, criteria, and scores that may be used to identify children with sepsis who are at high risk of progressing to multiple organ dysfunction or death. Data Sources:. We will identify eligible studies by searching the following databases: MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials. Study Selection:. We will include all randomized trials and cohort studies published between January 1, 2004, and March 16, 2020. Data Extraction:. Data extraction will include information related to study characteristics, population characteristics, clinical criteria, and outcomes. Data Synthesis:. We will calculate sensitivity and specificity of each criterion for predicting sepsis and conduct a meta-analysis if the data allow. We will also provide pooled estimates of overall hospital mortality. Conclusions:. The potential risk factors, clinical criteria, and illness severity scores from this review which identify patients with infection who are at high risk of developing sepsis-associated organ dysfunction and/or progressing to multiple organ dysfunction or death will be used to inform the next steps of the Pediatric Sepsis Definition Taskforce.
