Squamous cell carcinoma arising in sacrococcygeal teratoma in an adult: A case report

Yasushi Tanaka; Ryota Nakanishi; Hirokuni Hazama; Taro Mori; Tetsuro Kawazoe; Kensuke Kudou; Yoko Zaitsu; Yuichi Hisamatsu; Koji Ando; Eiji Oki; Shinichi Aishima; Yoshinao Oda; Tomoharu Yoshizumi

doi:10.1016/j.hpr.2025.300773

Human Pathology Reports (Jun 2025)

Squamous cell carcinoma arising in sacrococcygeal teratoma in an adult: A case report

Yasushi Tanaka,
Ryota Nakanishi,
Hirokuni Hazama,
Taro Mori,
Tetsuro Kawazoe,
Kensuke Kudou,
Yoko Zaitsu,
Yuichi Hisamatsu,
Koji Ando,
Eiji Oki,
Shinichi Aishima,
Yoshinao Oda,
Tomoharu Yoshizumi

Affiliations

Yasushi Tanaka: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan; Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan; Corresponding author at: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Ryota Nakanishi: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Hirokuni Hazama: Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Taro Mori: Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Tetsuro Kawazoe: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Kensuke Kudou: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Yoko Zaitsu: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Yuichi Hisamatsu: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Koji Ando: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Eiji Oki: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Shinichi Aishima: Department of Scientific Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Yoshinao Oda: Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Tomoharu Yoshizumi: Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

DOI: https://doi.org/10.1016/j.hpr.2025.300773
Journal volume & issue: Vol. 40
p. 300773

Abstract

Read online

Sacrococcygeal teratomas (SCT) with malignant transformation to squamous cell carcinoma are extremely rare, with only few cases reported in the literature. Herein, we report on a case of a primary sacrococcygeal mature cystic teratoma with malignant transformation into a squamous cell carcinoma. A 53-year-old woman presented with dysuria and lower abdominal pain caused by a huge SCT. Computed tomography (CT), magnetic resonance imaging, and positron emission tomography/CT findings were suggestive of SCT with malignant transformation. The treatment involved robotic-assisted laparoscopic abdominoperineal resection and bilateral lymph node dissection. Histopathology revealed squamous cell carcinoma within the teratoma. Postoperatively, the patient underwent six cycles of paclitaxel-carboplatin chemotherapy and showed no signs of recurrence during the 1-year follow-up.

Published in Human Pathology Reports

ISSN: 2772-736X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Pathology
Website: https://www.journals.elsevier.com/human-pathology-reports

About the journal

Abstract

Keywords