Inhibitory Receptor Diffusion Dynamics

Abstract

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The dynamic modulation of receptor diffusion-trapping at inhibitory synapses is crucial to synaptic transmission, stability, and plasticity. In this review article, we will outline the progression of understanding of receptor diffusion dynamics at the plasma membrane. We will discuss how regulation of reversible trapping of receptor-scaffold interactions in combination with theoretical modeling approaches can be used to quantify these chemical interactions at the postsynapse of living cells.

Keywords

• diffusion-trapping
• inhibitory synapse
• GABAA receptor
• glycine receptor
• gephyrin
• single-particle tracking