Antecedent chromatin organization determines cGAS recruitment to ruptured micronuclei

Kate M. MacDonald; Shirony Nicholson-Puthenveedu; Maha M. Tageldein; Sarika Khasnis; Cheryl H. Arrowsmith; Shane M. Harding

doi:10.1038/s41467-023-36195-8

Nature Communications (Feb 2023)

Antecedent chromatin organization determines cGAS recruitment to ruptured micronuclei

Kate M. MacDonald,
Shirony Nicholson-Puthenveedu,
Maha M. Tageldein,
Sarika Khasnis,
Cheryl H. Arrowsmith,
Shane M. Harding

Affiliations

Kate M. MacDonald: Department of Medical Biophysics, University of Toronto
Shirony Nicholson-Puthenveedu: Princess Margaret Cancer Center, University Health Network
Maha M. Tageldein: Department of Medical Biophysics, University of Toronto
Sarika Khasnis: Princess Margaret Cancer Center, University Health Network
Cheryl H. Arrowsmith: Department of Medical Biophysics, University of Toronto
Shane M. Harding: Department of Medical Biophysics, University of Toronto

DOI: https://doi.org/10.1038/s41467-023-36195-8
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 15

Abstract

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DNA damage-induced micronuclei are linked to downstream viral signalling through the cGAS pattern recognition receptor. Here, the authors identify features of micronuclei chromatin that determine cGAS-MN recruitment and associated pathway activation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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