Epidemiology and Antimicrobial Resistance Profiles of Bacterial Isolates from Clinical Specimens at Felege Hiwot Comprehensive Specialized Hospital in Ethiopia: Retrospective Study
Mulat Erkihun,
Ayenew Assefa,
Biruk Legese,
Andargachew Almaw,
Ayenew Berhan,
Birhanu Getie,
Teklehaimanot Kiros,
Alemie Fentie,
Shewaneh Damtie,
Tahir Eyayu,
Birhanemaskal Malkamu,
Yenealem Solomon,
Bekele Sharew,
Zelalem Asmare,
Molla Getie,
Aklesya Enkobahry,
Bayu Ayele,
Degu Ashagrie
Affiliations
Mulat Erkihun
Department of Medical Laboratory Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor P.O. Box 272, Ethiopia
Ayenew Assefa
Department of Medical Laboratory Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor P.O. Box 272, Ethiopia
Biruk Legese
Department of Medical Laboratory Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor P.O. Box 272, Ethiopia
Andargachew Almaw
Department of Medical Laboratory Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor P.O. Box 272, Ethiopia
Ayenew Berhan
Department of Medical Laboratory Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor P.O. Box 272, Ethiopia
Birhanu Getie
Department of Medical Laboratory Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor P.O. Box 272, Ethiopia
Teklehaimanot Kiros
Department of Medical Laboratory Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor P.O. Box 272, Ethiopia
Alemie Fentie
Department of Medical Laboratory Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor P.O. Box 272, Ethiopia
Shewaneh Damtie
Department of Medical Laboratory Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor P.O. Box 272, Ethiopia
Tahir Eyayu
Department of Medical Laboratory Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor P.O. Box 272, Ethiopia
Birhanemaskal Malkamu
Department of Medical Laboratory Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor P.O. Box 272, Ethiopia
Yenealem Solomon
Department of Medical Laboratory Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor P.O. Box 272, Ethiopia
Bekele Sharew
Department of Medical Laboratory Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor P.O. Box 272, Ethiopia
Zelalem Asmare
Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Injibara University, Injibara P.O. Box 40, Ethiopia
Molla Getie
Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Injibara University, Injibara P.O. Box 40, Ethiopia
Aklesya Enkobahry
Department of Biomedical Sciences, College of Medicine and Health Sciences, Injibara University, Injibara P.O. Box 40, Ethiopia
Bayu Ayele
Laboratory Service Unit, Felege Hiwot Comprehensive Specialized Hospital, Bahir Dar P.O. Box 47, Ethiopia
Degu Ashagrie
Laboratory Service Unit, Felege Hiwot Comprehensive Specialized Hospital, Bahir Dar P.O. Box 47, Ethiopia
Background: Bacterial infections constitute a large portion of infectious disorders. The location of culture-positive specimens and profiles of antibiotic resistance for common pathogens have been the focal points of subsequent investigations. Methodology: The diagnosis of microbiology was carried out using traditional culture techniques. In accordance with Clinical and Laboratory Standards Institute guidelines, the Kirby–Bauer disk diffusion method was employed for antimicrobial susceptibility analysis. The data were extracted from WHONET 2022 software version 22.5.5 and analyzed using SPSS software. Results: In total, 2489 pathogens were isolated from 2073 patients in three consecutive years. About 768 (34.9%) of the isolates were from the neonatal intensive care unit and the pediatric wards, and 63.2% isolates were from blood specimens. The ESKAPE pathogens were predominant (67%). About 100 Enterobacteriaceae family member bacteria were resistant to carbapenem drugs, and 320 isolates of this family were expected to be beta lactamase producers. A total of 120 methicillin-resistant S. aureus isolates were also identified. Conclusions: Among the isolates, ESKAPE pathogens accounted for the greatest proportion. Most isolates were from the neonatal intensive care unit. A significant number of multidrug-resistant, extreme drug-resistant, and pandrug-resistant isolates were identified in the present study.
