N-stearoylethanolamine effect on the level of 11-hydroxycorticosteroids, cytokines IL-1β, IL-6 and TNFα in rats with nonspecific inflammation caused by thermal burn of skin

Abstract

The mechanisms of anti-inflammatory action of saturated N-acylethanolamine – N-stearoylethanolamine (NSE) were investigated on the rat model of nonspecific inflammation (thermal burns of the skin). The results showed that the NSE application in a form of aqueous suspension (10 mg/ml) on the damaged skin area during 12 days significantly accelerated the healing process of burned wounds. NSE also prevented the increase of 11-hydroxy­corticosteroids content in the blood of rats with burns. There was also found a significant decrease of cytokines (IL-1β, IL-6 and TNFα) levels under the NSE action. This way may be one of the mechanisms of NSE anti-inflammatory action.

Keywords

• 11-hydroxycorticosteroids
• burn trauma of skin
• IL-1β
• IL-6
• N-stearoylethanolamine
• nonspecific inflammation
• TNFα