Nature Communications (Jul 2022)

A phylogenetically-restricted essential cell cycle progression factor in the human pathogen Candida albicans

  • Priya Jaitly,
  • Mélanie Legrand,
  • Abhijit Das,
  • Tejas Patel,
  • Murielle Chauvel,
  • Corinne Maufrais,
  • Christophe d’Enfert,
  • Kaustuv Sanyal

DOI
https://doi.org/10.1038/s41467-022-31980-3
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 18

Abstract

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Chromosomal instability caused by cell division errors is associated with antifungal drug resistance in fungal pathogens. Here, Jaitly et al. identify several genes involved in chromosomal stability in Candida albicans, including a phylogenetically restricted gene encoding an essential cell-cycle progression factor.