Tetrahedron Chem (Mar 2024)

Enantioselective α-heterofunctionalization reactions of catalytically generated C1-Lewis base enolates

  • Magdalena Piringer,
  • Lotte Stockhammer,
  • Lukas Vogl,
  • David Weinzierl,
  • Paul Zebrowski,
  • Mario Waser

Journal volume & issue
Vol. 9
p. 100063

Abstract

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Chiral Lewis base (LB) organocatalysis has emerged as a powerful covalent catalysis concept which allows for highly selective asymmetric C–C and C-heteroatom bond formations. Considering significant recent progress in the development of strategies to access α-heterofunctionalized carboxylic acid derivatives under chiral LB catalysis, we wish to summarize the most significant concepts and advances in this field within this mini review now.

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