Differential roles for DNAJ isoforms in HTT-polyQ and FUS aggregation modulation revealed by chaperone screens

Kinneret Rozales; Amal Younis; Naseeb Saida; Anatoly Meller; Hodaya Goldman; Lior Kellerman; Ronit Heinrich; Shai Berlin; Reut Shalgi

doi:10.1038/s41467-022-27982-w

Nature Communications (Jan 2022)

Differential roles for DNAJ isoforms in HTT-polyQ and FUS aggregation modulation revealed by chaperone screens

Kinneret Rozales,
Amal Younis,
Naseeb Saida,
Anatoly Meller,
Hodaya Goldman,
Lior Kellerman,
Ronit Heinrich,
Shai Berlin,
Reut Shalgi

Affiliations

Kinneret Rozales: Department of Biochemistry, Rappaport Faculty of Medicine, Technion–Israel Institute of Technology
Amal Younis: Department of Biochemistry, Rappaport Faculty of Medicine, Technion–Israel Institute of Technology
Naseeb Saida: Department of Biochemistry, Rappaport Faculty of Medicine, Technion–Israel Institute of Technology
Anatoly Meller: Department of Biochemistry, Rappaport Faculty of Medicine, Technion–Israel Institute of Technology
Hodaya Goldman: Department of Biochemistry, Rappaport Faculty of Medicine, Technion–Israel Institute of Technology
Lior Kellerman: Department of Biochemistry, Rappaport Faculty of Medicine, Technion–Israel Institute of Technology
Ronit Heinrich: Department of Neuroscience, Rappaport Faculty of Medicine, Technion–Israel Institute of Technology
Shai Berlin: Department of Neuroscience, Rappaport Faculty of Medicine, Technion–Israel Institute of Technology
Reut Shalgi: Department of Biochemistry, Rappaport Faculty of Medicine, Technion–Israel Institute of Technology

DOI: https://doi.org/10.1038/s41467-022-27982-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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Here, using quantitative screens in human cells, the authors reveal distinct effects of naturally-occurring DNAJ chaperone isoforms on pathological aggregation of the Huntington’s disease-associated HTT-polyQ and the ALS-related mutant FUS.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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