Planar chiral 2-(trifluoromethyl)quinoline-fused ferrocenes via palladium(0)-catalyzed C-H functionalization of trifluoroacetimidoyl chlorides

An-An Zhang; Chao Chen; Yushen Gao; Mingyang Mo; Ren-Zeng Shen; Yu-Heng Zhang; Naoki Ishida; Masahiro Murakami; Lantao Liu

Green Synthesis and Catalysis (Aug 2021)

Planar chiral 2-(trifluoromethyl)quinoline-fused ferrocenes via palladium(0)-catalyzed C-H functionalization of trifluoroacetimidoyl chlorides

An-An Zhang,
Chao Chen,
Yushen Gao,
Mingyang Mo,
Ren-Zeng Shen,
Yu-Heng Zhang,
Naoki Ishida,
Masahiro Murakami,
Lantao Liu

Affiliations

An-An Zhang: Henan Engineering Laboratory of Green Synthesis for Pharmaceuticals, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China
Chao Chen: Henan Engineering Laboratory of Green Synthesis for Pharmaceuticals, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China
Yushen Gao: Henan Engineering Laboratory of Green Synthesis for Pharmaceuticals, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China
Mingyang Mo: Henan Engineering Laboratory of Green Synthesis for Pharmaceuticals, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China
Ren-Zeng Shen: Henan Engineering Laboratory of Green Synthesis for Pharmaceuticals, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China
Yu-Heng Zhang: Henan Engineering Laboratory of Green Synthesis for Pharmaceuticals, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China
Naoki Ishida: Department of Synthetic Chemistry and Biological Chemistry, Kyoto University, Kyoto 615-8510, Japan
Masahiro Murakami: Department of Synthetic Chemistry and Biological Chemistry, Kyoto University, Kyoto 615-8510, Japan
Lantao Liu: Henan Engineering Laboratory of Green Synthesis for Pharmaceuticals, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China; College of Chemistry, Zhengzhou University, Zhengzhou 450001, China; Beijing National Laboratory for Molecular Sciences (BNLMS), College of Chemistry, Peking University, Beijing 100871, China; Corresponding author. Henan Engineering Laboratory of Green Synthesis for Pharmaceuticals, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, China.

Journal volume & issue: Vol. 2, no. 3
pp. 311 – 314

Abstract

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Catalytic enantioselective synthesis of planar chiral 2-(trifluoromethyl)quinoline-fused ferrocenes has been achieved through Pd(0)-catalyzed C-H functionalization with trifluoroacetimidoyl chlorides as electrophilics. With commercially available ligand and palladium precursor, the reaction proceeds smoothly generating 2-perfluoroalkylated quinoline-fused ferrocenes in high yields and enantioselectivities.

Published in Green Synthesis and Catalysis

ISSN: 2666-5549 (Online)
Publisher: KeAi Communications Co. Ltd.
Country of publisher: China
LCC subjects: Technology: Chemical technology; Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.keaipublishing.com/en/journals/green-synthesis-and-catalysis/

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