Biomedicines (Sep 2021)

NF-κB-Dependent and -Independent (Moonlighting) IκBα Functions in Differentiation and Cancer

  • Lluís Espinosa,
  • Laura Marruecos

DOI
https://doi.org/10.3390/biomedicines9091278
Journal volume & issue
Vol. 9, no. 9
p. 1278

Abstract

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IκBα is considered to play an almost exclusive role as inhibitor of the NF-κB signaling pathway. However, previous results have demonstrated that SUMOylation imposes a distinct subcellular distribution, regulation, NF-κB-binding affinity and function to the IκBα protein. In this review we discuss the main alterations of IκBα found in cancer and whether they are (most likely) associated with NF-κB-dependent or NF-κB-independent (moonlighting) activities of the protein.

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