Nature Communications (Jan 2021)
Improvement of obesity-associated disorders by a small-molecule drug targeting mitochondria of adipose tissue macrophages
- Yawei Wang,
- Binlin Tang,
- Lei Long,
- Peng Luo,
- Wei Xiang,
- Xueru Li,
- Huilan Wang,
- Qingzhi Jiang,
- Xu Tan,
- Shenglin Luo,
- Huijuan Li,
- Ziwen Wang,
- Zelin Chen,
- Yu Leng,
- Zhongyong Jiang,
- Yang Wang,
- Le Ma,
- Rui Wang,
- Chunyu Zeng,
- Zujuan Liu,
- Yu Wang,
- Hongming Miao,
- Chunmeng Shi
Affiliations
- Yawei Wang
- Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University
- Binlin Tang
- Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University
- Lei Long
- Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University
- Peng Luo
- Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University
- Wei Xiang
- Department of Biochemistry and Molecular Biology, Third Military Medical University
- Xueru Li
- Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University
- Huilan Wang
- Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University
- Qingzhi Jiang
- Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University
- Xu Tan
- Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University
- Shenglin Luo
- Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University
- Huijuan Li
- Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University
- Ziwen Wang
- Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University
- Zelin Chen
- Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University
- Yu Leng
- Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University
- Zhongyong Jiang
- Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University
- Yang Wang
- Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University
- Le Ma
- Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University
- Rui Wang
- Department of Cardiology, Daping Hospital, Third Military Medical University
- Chunyu Zeng
- Department of Cardiology, Daping Hospital, Third Military Medical University
- Zujuan Liu
- Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University
- Yu Wang
- Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University
- Hongming Miao
- Department of Biochemistry and Molecular Biology, Third Military Medical University
- Chunmeng Shi
- Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University
- DOI
- https://doi.org/10.1038/s41467-020-20315-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Adipose tissue macrophages are central to controlling inflammation in the context of obesity. Here the authors present a new infrared dye (IR-61) that accumulates in the mitochondria of these cells resulting in anti-inflammatory effects that counter obesity-associated pathology in mice.
