8-Hydroxy-5-nitroquinoline as a C-nucleophilic reagent in the reaction of C, C-coupling with quinazoline

Abstract

The first example of the reaction of 5-nitro-8-hydroxyquinoline as a C-nucleophile with quinazoline is described. As a result of the reaction of C, C-coupling, a stable σ-adduct containing the drug nitroxalin on a heterocyclic carrier was obtained. The structure of the resulting adduct was confirmed by 2D 1H-13C HSQC, 1H-13C HMBC, and 1H-15N HMBC spectra.

Keywords

• 5-nitro-8-hydroxyquinoline
• quinazoline
• c, c-coupling