Using the air pouch model for assessing in vivo inflammatory activity of nanoparticles

Abstract

Denis Girard INRS – Institut Armand-Frappier/Université du Québec, Québec, QC, CanadaI would like to make some comments and clarifications regarding the article "Intradermal air pouch leukocytosis as an in vivo test for nanoparticles" recently published in the International Journal of Nanomedicine. In this study, Vandooren et al1 used the air pouch model for evaluating potential pro-inflammatory effects of nanoparticles (NPs). This model is certainly suitable for investigating the inflammatory process which occurs during sterile inflammation and is suitable for determining if an agent, including a given NP, possesses pro-inflammatory activity or not.View original paper by Vandooren and colleagues.