Journal of the International Association of Providers of AIDS Care (Mar 2018)

The Impact of Absolute CD4 Count and Percentage Discordance on Pneumocystis Jirovecii Pneumonia Prophylaxis in HIV-Infected Patients

  • Henry Anyimadu MD,
  • Chandra Pingili MD,
  • Vel Sivapalan MD,
  • Yael Hirsch-Moverman PhD,
  • Sharon Mannheimer MD

DOI
https://doi.org/10.1177/2325958218759199
Journal volume & issue
Vol. 17

Abstract

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Current guidelines suggest that HIV-infected patients should receive chemoprophylaxis against Pneumocystis jirovecii pneumonia (PJP) if they have a cluster determinant 4 (CD4) count 200 but CD4% 14 (29% versus 86%; odds ratio = 0.064, 95% confidence interval: 0.0168-0.2436; P < .0001). We emphasize monitoring both the absolute CD4 count and percentage to appropriately guide PJP primary and secondary prophylaxis.