New approach to heart rate control as mortality reduction method in cardiac patients: potential of a new If inhibitor, ivabradine

Abstract

Large-scale epidemiological studies have demonstrated that heart rate (HR) is an independent risk factor, increasing total, sudden and cardiovascular mortality risk. Ivabradine specifically binds to sinus node (SN) f-channels and reduces HR. Due to its specific SN action and selective If current inhibition, ivabradine dose-responsively reduces HR at rest and maximal physical exertion, without changes in mean blood pressure. It has been shown that ivabradine is not only well-tolerated, but also possesses anti-anginal and anti-ischemic effects, as potent as those for modern angina treatment agents: beta-blockers and calcium antagonists.

Keywords

• частота сердечных сокращений
• сердечно-сосудистая смертность
• ишемическая болезнь сердца
• стабильная стенокардия
• f-каналы
• ионные токи if
• ивабрадин