Crotonylation of PRKACA enhances PKA activity and promotes colorectal cancer development via the PKA-FAK-AKT pathway

• Jia-Yi Hou,
• Li-Juan Gao,
• Jing Shen,
• Lan Zhou,
• Jian-Yun Shi,
• Teng Sun,
• Shu-Lan Hao,
• De-Ping Wang,
• Ji-Min Cao

Affiliations

Jia-Yi Hou

Key Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Key Laboratory of Cellular Physiology of Shanxi Province, and the Department of Physiology, Shanxi Medical University, Taiyuan, Shanxi 030001, China; Department of Clinical Laboratory, Shanxi Provincial Academy of Traditional Chinese Medicine, Taiyuan, Shanxi 030012, China

Li-Juan Gao

Key Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Key Laboratory of Cellular Physiology of Shanxi Province, and the Department of Physiology, Shanxi Medical University, Taiyuan, Shanxi 030001, China

Jing Shen

Key Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Key Laboratory of Cellular Physiology of Shanxi Province, and the Department of Physiology, Shanxi Medical University, Taiyuan, Shanxi 030001, China

Lan Zhou

Key Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Key Laboratory of Cellular Physiology of Shanxi Province, and the Department of Physiology, Shanxi Medical University, Taiyuan, Shanxi 030001, China

Jian-Yun Shi

Key Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Key Laboratory of Cellular Physiology of Shanxi Province, and the Department of Physiology, Shanxi Medical University, Taiyuan, Shanxi 030001, China

Teng Sun

Key Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Key Laboratory of Cellular Physiology of Shanxi Province, and the Department of Physiology, Shanxi Medical University, Taiyuan, Shanxi 030001, China

Shu-Lan Hao

Oncology Department, Shanxi Provincial Academy of Traditional Chinese Medicine, Taiyuan, Shanxi 030012, China

De-Ping Wang

Key Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Key Laboratory of Cellular Physiology of Shanxi Province, and the Department of Physiology, Shanxi Medical University, Taiyuan, Shanxi 030001, China; Corresponding author.

Ji-Min Cao

Key Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Key Laboratory of Cellular Physiology of Shanxi Province, and the Department of Physiology, Shanxi Medical University, Taiyuan, Shanxi 030001, China; Corresponding author.