Case Reports in Hematology (Jan 2022)

Systemic Relapse in a Young Adult Patient with Primary CNS Diffuse Large B-Cell Lymphoma

  • Adam Khorasanchi,
  • Zachary Benson,
  • Misty Hall,
  • Nelya Ebadirad,
  • Mohammad H. Gharavi,
  • Patrick Willard,
  • Miranda Chimzar,
  • John McKay,
  • Gary Simmons,
  • Victor Yazbeck

DOI
https://doi.org/10.1155/2022/7139661
Journal volume & issue
Vol. 2022

Abstract

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Primary central nervous system diffuse large B-cell lymphoma (PCNS-DLBCL) is a rare form of non-Hodgkin’s lymphoma, characterized by an aggressive disease course. While CNS relapse is common, systemic relapse is rare with no consensus on optimal treatment. This paper presents an unusual case of advanced PCNS-DLBCL with systemic relapse, including adrenal gland involvement. A review of the existing literature and a discussion on the management of systemic relapse in PCNS-DLBCL is also provided.