Nature Communications (Sep 2019)
Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases
- Jiyuan An,
- Puya Gharahkhani,
- Matthew H. Law,
- Jue-Sheng Ong,
- Xikun Han,
- Catherine M. Olsen,
- Rachel E. Neale,
- John Lai,
- Tom L. Vaughan,
- Ines Gockel,
- René Thieme,
- Anne C. Böhmer,
- Janusz Jankowski,
- Rebecca C. Fitzgerald,
- Johannes Schumacher,
- Claire Palles,
- BEACON,
- 23andMe Research Team,
- David C. Whiteman,
- Stuart MacGregor
Affiliations
- Jiyuan An
- Statistical Genetics, QIMR Berghofer Medical Research Institute
- Puya Gharahkhani
- Statistical Genetics, QIMR Berghofer Medical Research Institute
- Matthew H. Law
- Statistical Genetics, QIMR Berghofer Medical Research Institute
- Jue-Sheng Ong
- Statistical Genetics, QIMR Berghofer Medical Research Institute
- Xikun Han
- Statistical Genetics, QIMR Berghofer Medical Research Institute
- Catherine M. Olsen
- Cancer Control, QIMR Berghofer Medical Research Institute
- Rachel E. Neale
- Cancer Aetiology and Prevention, QIMR Berghofer Medical Research Institute
- John Lai
- Centre for Epidemiology and Biostatistics, The University of Melbourne
- Tom L. Vaughan
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Ines Gockel
- Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig
- René Thieme
- Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig
- Anne C. Böhmer
- Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn
- Janusz Jankowski
- Royal College of Surgeons in Ireland
- Rebecca C. Fitzgerald
- Medical Research Council (MRC) Cancer Unit, Hutchison-MRC Research Centre and University of Cambridge
- Johannes Schumacher
- Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn
- Claire Palles
- Institute of Cancer and Genomic Sciences, University of Birmingham
- BEACON
- International Barrett’s and Esophageal Adenocarcinoma Consortium
- 23andMe Research Team
- David C. Whiteman
- Cancer Control, QIMR Berghofer Medical Research Institute
- Stuart MacGregor
- Statistical Genetics, QIMR Berghofer Medical Research Institute
- DOI
- https://doi.org/10.1038/s41467-019-11968-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 10
Abstract
Gastroesophageal reflux disease (GERD) is a major risk factor for Barret’s esophagus (BE) and esophageal adenocarcinoma (EA). Here, An et al. report 25 genetic loci for GERD, many of which associate with BE and EA or with other traits such as BMI.
