THE ANTIOXIDANT EFFECTS OF CAPPARIS OVATA AND DEFERASIROX IN PATIENTS WITH THALASSEMIA MAJOR

Abstract

Ironoverload and auto-oxidation of unpaired globin chains are the main causes of oxidative stress inpatients with thalassemia major. In thepresent study, we aimed to investigate the antioxidant effects of capparisovatta and deferasirox in thalassemic patients.A total 40 patients with thalassemia major aged between7-30 years, who have been taken regular red cell transfusion and chelation (Deferasirox:30 mg/kg/day) forone year are involved. They were dividedinto two groups as control and studygroup randomly. Both study and control groupswere followed by regular transfusion and chelationtherapy. In addition study group have been taken the marmalade of driedcapparis ovata the breakfast with a daily dose of 12.5 gryounger than 10 years and 25 gr older than 10 years for 6 months. Hematological, biochemical parameters,ferritin at every month and antioxidant enzymes (MDA, CAT, GPX, SOD) were measuredat the beginning and at the end of the study. There was a significant difference between initial andfinal parameters of the MDA levels instudy group. SODlevels also decreased statistically in bothof the groups, CAT and GPX levels didn’tdecrease significantly in both of thegroups. Ferritin levels declinedsignificiantly both in control and study group. As conclusion, our findings suggest that combination of capparis ovata with deferasirox may have additive effecton decreasing the oxidative damage and hepatoxicity. This is preliminary work, it needs further works.

Keywords

• Thalassemia
• antioxidants
• capparis ovata
• deferasirox