Biology of IL-36 Signaling and Its Role in Systemic Inflammatory Diseases

Zhi-Chao Yuan; Wang-Dong Xu; Xiao-Yan Liu; Xing-You Liu; An-Fang Huang; Lin-Chong Su

doi:10.3389/fimmu.2019.02532

Frontiers in Immunology (Oct 2019)

Biology of IL-36 Signaling and Its Role in Systemic Inflammatory Diseases

Zhi-Chao Yuan,
Wang-Dong Xu,
Xiao-Yan Liu,
Xing-You Liu,
An-Fang Huang,
Lin-Chong Su

Affiliations

Zhi-Chao Yuan: Department of Evidence-Based Medicine, School of Public Health, Southwest Medical University, Luzhou, China
Wang-Dong Xu: Department of Evidence-Based Medicine, School of Public Health, Southwest Medical University, Luzhou, China
Xiao-Yan Liu: Department of Nutrition and Food Hygiene, School of Public Health, Southwest Medical University, Luzhou, China
Xing-You Liu: School of Traditional Chinese Medicine, Southwest Medical University, Luzhou, China
An-Fang Huang: Department of Rheumatology and Immunology, Affiliated Hospital of Southwest Medical University, Luzhou, China
Lin-Chong Su: Department of Rheumatology and Immunology, Minda Hospital of Hubei Minzu University, Enshi, China

DOI: https://doi.org/10.3389/fimmu.2019.02532
Journal volume & issue: Vol. 10

Abstract

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Interleukin (IL)-36 is a member of the IL-1 superfamily and includes three agonists (IL-36α, IL-36β, and IL-36γ) and an antagonist (IL-36Ra). IL-36 agonists bind to heterodimeric receptor complexes. Then, the heterotrimer complexes signal via intracellular functional domains, binding to downstream signaling proteins and inducing inflammatory responses. In this review, we summarized the current knowledge about the biological role of IL-36 and its correlation with systemic inflammatory diseases. The information collected will help to increase the understanding of the potential of IL-36 and may give clues for developing novel therapeutic strategies.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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Abstract

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