The FIB-4 scores in the emergency department to predict the outcomes of COVID-19 patients in taiwan
Chia-Yu Liu,
San-Fang Chou,
Pei-Ying Chiang,
Jen-Tang Sun,
Kuang-Chau Tsai,
Fu-Shan Jaw,
Chung-Ta Chang,
Chieh-Min Fan,
Yuan-Hui Wu,
Peng-Yu Lee,
Chia-Ying Hsieh,
Jie-Ming Chen,
Chien-Chieh Hsieh
Affiliations
Chia-Yu Liu
Department of Radiology, Taipei Veterans General Hospital, Taipei City, Taiwan
San-Fang Chou
Department of Medical Research, Far Eastern Memorial Hospital, New Taipei City, Taiwan
Pei-Ying Chiang
Division of Hospital Medicine, Department of Internal Medicine, Far Eastern Memorial Hospital, Taiwan
Jen-Tang Sun
Department of Emergency Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan
Kuang-Chau Tsai
Department of Emergency Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan
Fu-Shan Jaw
Department of Biomedical Engineering, National Taiwan University, Taipei City, Taiwan
Chung-Ta Chang
Department of Emergency Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Graduate Institute of Medicine, Yuan Ze University, Taoyuan, Taiwan
Chieh-Min Fan
Department of Emergency Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan
Yuan-Hui Wu
Department of Emergency Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan
Peng-Yu Lee
Department of Emergency Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan
Chia-Ying Hsieh
Department of Medical Education, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan
Jie-Ming Chen
Department of Emergency Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan
Chien-Chieh Hsieh
Department of Biomedical Engineering, National Taiwan University, Taipei City, Taiwan; Department of Emergency Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Graduate Institute of Medicine, Yuan Ze University, Taoyuan, Taiwan; Department of Emergency Medicine, Ten Chan General Hospital, Zhongli Dist, Taoyuan City, Taiwan; Corresponding author. Department of Biomedical Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Da'an Dist., Taipei City, 106, Taiwan.
Objective: We aimed to determine the reliability of using the Fibrosis-4 (FIB-4) index in COVID-19 patients without underlying liver illness. Method: We employed multivariate logistic regression to identify variables that exhibited statistically significant influence on the ultimate outcome. Multilayer perceptron analysis was employed to develop a prediction model for the FIB-4 index concerning ICU admission and intubation rates. However, the scarcity of cases rendered the assessment of the mortality rate unfeasible. We plotted ROC curves to analyze the predictive strength of the FIB-4 index across various age groups. Result: In univariate logistic regression, only the FIB-4 index and respiratory rate demonstrated statistical significance on all poor outcomes. The FIB-4 index for mortality prediction had an ROC and AUC of 0.863 (95% CI: 0.781–0.9444). It demonstrates predictive power across age groups, particularly for age ≥65 (AUC: 0.812, 95% CI: 0.6571–0.9673) and age <65 (AUC: 0.878, 95% CI: 0.8012–0.9558). Its sensitivity for intubation and ICU admission prediction is suboptimal. Conclusion: FIB-4 index had promising power in prediction of mortality rate in all age groups.
